Protein Details: 5-hydroxytryptamine receptor 3A

Protein ID

ICDB_Pro_0534

Protein Name

5-hydroxytryptamine receptor 3A

Gene Name

HTR3A; 5HT3R; HTR3

Organism

Homo sapiens (Human)

Length

478 amino acids

AlphaFoldDB

AF-P46098-F1-model_v4.pdb

Function

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes;which when activated cause fast;depolarizing responses in neurons.

Sequence

MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

include Serotonin Syndrome and Irritable Bowel Syndrome

Location

Expressed in cerebral cortex;amygdala;hippocampus;and testis. Detected in monocytes of the spleen and tonsil;in small and large intestine;uterus;prostate;ovary and placenta.

DOI ID

10.1111/j.1749-6632.1998.tb10196.x; 10.1016/s0028-3908(99)00116-1; 10.1016/j.ygeno.2003.09.023; 10.1038/ng1285; 10.1038/nature04632; 10.1101/gr.2596504; 10.1038/16941; 10.1074/jbc.274.43.30799; 10.1038/nature01788; 10.1074/jbc.m414341200; 10.1124/mol.106.032144; 10.1007/s10067-004-0927-2; 10.1016/j.biopsych.2005.11.008

RefSeq

NP_000860.2 [P46098-1]; NP_001155244.1 [P46098-3]; NP_998786.2 [P46098-2]